Using Multiple Procotols

It is possible to use multiple protocols for communication with remoting, this is because the result of the Remoting module is either a WebPart in case of Suave or a HttpHandler in case of Giraffe or Saturn. In all cases, you can compose multiple resuling API's the same way you do with normal WebParts or HttpHandlers using the choose combinator:

Suave

let firstApi = 
    Remoting.createApi()
    |> Remoting.fromValue firstProtocol
    |> Remoting.buildWebpart 

let secondApi = 
    Remoting.createApi()
    |> Remoting.fromValue secondProtocol
    |> Remoting.buildWebpart 

let combinedApi = choose [firstApi; secondApi]

Giraffe or Saturn

let firstApi = 
    Remoting.createApi()
    |> Remoting.fromValue firstProtocol
    |> Remoting.buildHttpHandler 

let secondApi = 
    Remoting.createApi()
    |> Remoting.fromValue secondProtocol
    |> Remoting.buildHttpHandler 

let combinedApi = choose [firstApi; secondApi]